MULTIPLE-OBJECTIVE DESIGNS IN A DOSE-RESPONSE EXPERIMENT
نویسندگان
چکیده
منابع مشابه
On Multiple-Objective Nonlinear Optimal Designs
Experiments with multiple objectives form a staple diet of modern scientific research. Deriving optimal designs with multiple objectives is a long-standing challenging problem with few tools available. The few existing approaches cannot provide a satisfied solution in general: either the computation is very expensive or a satisfied solution is not guaranteed. There is need for a general approac...
متن کاملAdaptive dose-finding designs to identify multiple doses that achieve multiple response targets
The objective of the DILT1D trial is to identify doses of interleukin-2 that achieve targeted increases in the T regulatory cell population in recently diagnosed type 1 diabetes. DILT1D aims to accurately identify a minimally effective dose and a maximal dose in a limited number of patients (40) that may be repeatedly administered in later phase trials. The dose is administered subcutaneously s...
متن کاملMultiple-objective Optimal Designs for the Logit Model
The toxicity and eeciency of a drug must be determined before it is approved for general use. Quantal dose-response experiments are routinely conducted to examine the response rates at dose levels of interest. Multiple-objective optimal designs for such studies are found and compared with the popular equal allocation rules.
متن کاملFast, multiple optimizations of quadratic dose objective functions in IMRT.
Inverse treatment planning for intensity-modulated radiotherapy may include time consuming, multiple minimizations of an objective function. In this paper, methods are presented to speed up the process of (repeated) minimization of the well-known quadratic dose objective function, extended with a smoothing term that ensures generation of clinically acceptable beam profiles. In between two subse...
متن کاملMultiple Comparison Procedures in Dose Response Studies
Dose–response studies are useful in Phase II and Phase III clinical trials to evaluate efficacy and toxicity of a drug in order to determine its effective and safe ranges. A zero dose is generally included as a control against which higher doses are compared. This naturally leads to multiple comparisons. The ordered nature of doses suggests the use of stepwise multiple test procedures. The purp...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Biopharmaceutical Statistics
سال: 2000
ISSN: 1054-3406,1520-5711
DOI: 10.1081/bip-100101009